A scholarly edition of The Clarendon Edition of the Works of John Locke: Correspondence: Letters 849-1241 by E. S. de Beer. The edition presents an authoritative text, together with an introduction, commentary notes, and scholarly apparatus.

This paper begins to explore how corporate social responsibility (CSR) has evolved in Mexico. It looks at Mexico's social and political history to see the values that shaped expectations about how Mexican firms should address the needs and desires of their stakeholders in various periods in the 20th century. Particular attention is given to firms in Monterrey because they pioneered a form of company paternalism that reflected early CSR initiatives. Finally the paper briefly examines some contemporary CSR practices by large (...) Mexican firms. The paper begins to fill a gap in the business-andsociety literature about CSR practices outside the U.S. and Western European countries, which have received most attention by business-and-society scholars. (shrink)

This paper begins to examine the question of where societal expectations about the nature of corporate social responsibility come from. In particular, we begin to consider arguments about how a country’s stage of economic development affects the kinds of social responsibility expectations that firms face and then how the nature of a country’s civil society might affect CSR expectations. The factors that should be taken into account for future empirical research are also considered.

The relationship between individuals' creativity and their ethical ideologies appears to be complex. Applying Forsyth's (1980, 1992) personal moral philosophy model which consists of two independent ethical ideology dimensions, idealism and relativism, we hypothesized and found support for a positive relationship between creativity and relativism. It appears that creative people are less likely than non-creative people to follow universal rules in their moral decision making. However, contrary to our hypothesis and the general stereotype that creative people are less caring about (...) others, we found a positive relationship between creativity and idealism. These findings indicate that highly creative people are likely to be what Forsyth called "situationists," individuals with both an ethic of caring and a pragmatic moral decision-making style. The finding that creative individuals tend to be situationists, and particularly that they tend to be high in idealism, appears to refute the line of reasoning that argues for a "creative personality" characterized in part by social insensitivity. Understanding the relationship between creativity and ethical ideologies has important implications for researchers, managers and teachers. (shrink)

This book reinvigorates the philosophical treatment of the nature, purpose, and meaning of thought in today’s universities. The wider discussion about higher education has moved from a philosophical discourse to a discourse on social welfare and service, economics, and political agendas. This book reconnects philosophy with the central academic concepts of thought, reason, and critique and their associated academic practices of thinking and reasoning. Thought in this context should not be considered as a merely mental or cognitive construction, still less (...) a cloistered college, but a fully developed individual and social engagement of critical reflection and discussion with the current pressing disciplinary, political, and philosophical issues. The editors hold that the element of thought, and the ability to think in a deep and groundbreaking way is, still, the essence of the university. But what does it mean to think in the university today? And in what ways is thought related not only to the epistemological and ontological issues of philosophical debate, but also to the social and political dimensions of our globalised age? In many countries, the state is imposing limitations on universities, dismissing or threatening academics who speak out critically. With this volume, the editors ask questions such as: What is the value of thought? What is the university’s proper relationship to thought? To give the notion of thought a thorough philosophical treatment, the book is divided into in three parts. The focus moves from an epistemological perspective in Part I, to a focus on existence and values in higher education in Part II, and then to a societal-oriented focus on the university in Part III. All three parts, in their own ways, debate the notion of thought in higher education and the university as a thinking form of being. (shrink)

Over the past 40 years, scholars and practitioners of public relations have often cast public relations workers in the role of the public relations-person-as-corporate-conscience. This work, however, maintains that this construct is so problematic that invoking it is of negligible use in addressing ethical issues that emerge during a crisis. In fact, a complex crisis, such as the Jahi McMath “brain death” case at Children’s Hospital Oakland, demonstrates the need to abandon the PRPaCC construct to better engage affected stakeholders, including (...) “outsiders” to the organization, who often determine whether an organization is facing a crisis. Through an examination of both the concept of the PRPaCC and the McMath crisis, this work makes the case for moving beyond the PRPaCC construct in favor of a more modest role for the public relations person: facilitating widespread ethical deliberation and discussion throughout an organization, potentially helping the organization alleviate concerns that contribute to crises. (shrink)

The attribution of sentience or consciousness to plants is currently a topic of debate among biologists and philosophers. The claim that plants are conscious is based on three arguments: (i) plants, like all living organisms, are sentient (biopsychism); (ii) there is a strong analogy between the phloem transport system of plants and the nervous system of animals; and (iii) plants are the cognitive equals of sentient animals. On the basis of a model of consciousness that spells out criteria for assigning (...) sentience to a living organism and presents a diagnostic evolutionary marker of consciousness, we argue that these arguments are flawed and discuss some of the ethical issues they raise. (shrink)

This paper begins to explore how corporate social responsibility (CSR) has evolved in Mexico. It looks at Mexico's social and political history to see the values that shaped expectations about how Mexican firms should address the needs and desires of their stakeholders in various periods in the 20th century. Particular attention is given to firms in Monterrey because they pioneered a form of company paternalism that reflected early CSR initiatives. Finally the paper briefly examines some contemporary CSR practices by large (...) Mexican firms. The paper begins to fill a gap in the business-andsociety literature about CSR practices outside the U.S. and Western European countries, which have received most attention by business-and-society scholars. (shrink)

This manual is the product of a normative research program carried out over four years with Spanish-speaking populations in two geographically distinct regions: Madrid, Spain and the USA/Mexico border region. The manual describes a comprehensive system of procedures and normative data designed to assist the clinical researcher and the clinical practitioner in the neuropsychological assessment and diagnosis of adults whose main language is Spanish. Together the procedures comprise a brief and practical battery of eight tests for a basic examination of (...) attention, learning and memory, and executive function. The level of performance on these tests is assessed according to normative data. This is accomplished by adjusting test scores according to demographic criteria that simultaneously take into account the traditional factors of age and education, as well as the patient's place of origin. (shrink)

A considerable literature exists regard-ing the moral obligation to keep one's promises. Several authors have focused on the exceptional circumstances which may or should excuse this moral duty. Less frequently discussed is the question of how this general moral obligation and its possible exceptions play out in the context of negotiable written promises to pay money, i.e., so-called "commercial paper."This paper focuses on the application of the legal rules governing commercial paper, and on the ethical implications involved in the application (...) of those rules. More specifically, it asks whether the assertion of the technical doctrine known as "holder in due course," and the denial of that status in some cases, promotes ethical behavior in the marketplace. By examining the circumstances of one case, involving a substantial investment and a large bank, I hope to shed some light on how the legal and ethical rules do in fact "intersect.". (shrink)

Subcreative sets, introduced by Blum, are known to coincide with the effectively speedable sets. Subcreative sets are shown to be the complete sets with respect to S-reducibility, a special case of Turing reducibility. Thus a set is effectively speedable exactly when it contains the solution to the halting problem in an easily decodable form. Several characterizations of subcreative sets are given, including the solution of an open problem of Blum, and are used to locate the subcreative sets with respect to (...) the complete sets of other reducibilities. It is shown that q-cylindrification is an order-preserving map from the r.e. T-degrees to the r.e. S-degrees. Consequently, T-complete sets are precisely the r.e. sets whose q-cylindrifications are S-complete. (shrink)

DNA joining enzymes play an essential role in the maintenance of genomic integrity and stability. Three mammalian genes encoding DNA ligases, LIG1, LIG3 and LIG4, have been identified. Since DNA ligase II appears to be derived from DNA ligase III by a proteolytic mechanism, the three LIG genes can account for the four biochemically distinct DNA ligase activities, DNA ligases I, II, III and IV, that have been purified from mammalian cell extracts. It is probable that the specific cellular roles (...) of these enzymes are determined by the proteins with which they interact. The specific involvement of DNA ligase I in DNA replication is mediated by the non‐catalytic amino‐terminal domain of this enzyme. Furthermore, DNA ligase I participates in DNA base excision repair as a component of a multiprotein complex. Two forms of DNA ligase III are produced by an alternative splicing mechanism. The ubiqitously expressed DNA ligase III‐α forms a complex with the DNA single‐strand break repair protein XRCC1. In contrast, DNA ligase III‐β, which does not interact with XRCC1, is only expressed in male meiotic germ cells, suggesting a role for this isoform in meiotic recombination. At present, there is very little information about the cellular functions of DNA ligase IV. (shrink)

The article comprises three parts. Part I contains an overview of the areas in the analysis of modern French philosophy that have been of the greatest relevance to Russian researchers over the last years. We conclude that numerous aspects of the French philosophical thought of the twentieth century are well represented in the research of Russian authors, who also point out the emerging trends in its development. Part II deals with the development of analytic philosophy in Russia within the framework (...) of such areas as “critique of bourgeois philosophy”, a purely ideological stand only nominally related to philosophy, logic, and the history of philosophy and theoretical research. Part III contains a periodization of the history of phenomenology in Russia, pointing out the most important achievements of the contemporary Russian scholars of phenomenology as well as their understanding of the essence, the problems, and the aims of phenomenological philosophy. We also indicate the tendencies within the development of the discipline in the Russian Federation. (shrink)

Quito published her book The State of Philosophy in the Philippines in 1983. When the book was already out for fifteen years, I undertook a re-reading of its identified four clusters of reasons for the underdevelopment of Filipino philosophy, and hope for development in 1999, through an article “Re-Reading Emerita Quito’s Thoughts Concerning the Underdevelopment of Filipino Philosophy.” Thirty-six years after the publication of Quito’s book, and twenty years after the publication of my re-reading, this paper looks back again on (...) Quito’s four clusters of reasons and hope, as well as on my re-reading of such reasons and hope, with the intention of sharpening our collective diagnosis on what continue to cause the underdevelopment of Filipino philosophy, as well as imagining more realistic pathways towards its more robust development. This paper, therefore, has two substantive sections: the first is an exposition of Quito’s four clusters of causes and hope, accompanied by my commentaries on such four causes and hope; and the second is my present critical reflection on Quito’s thirty-four-year-old diagnosis and hope, as well as on my twenty-year-old commentary. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Picturing Hegel: An Illustrated Guide to Hegel’s Encyclopaedia LogicJames A. Dunson IIIJulie E. Maybee. Picturing Hegel: An Illustrated Guide to Hegel’s Encyclopaedia Logic. Lanham, MD: Lexington Books, 2009. Pp. xxvii + 639. Paper, $56.95.If Hegel were alive to read an illustrated guide to his Encyclopaedia Logic, he might not immediately appreciate the project. Not only did he consider “picture-thinking” deficient in comparison to conceptual thinking, but he regarded (...) the Encyclopaedia Logic as a text suitable for German students. In her recent book, Picturing Hegel, Julie Maybee acknowledges these ironies and proceeds to guide those of us who need a little extra help in understanding Hegel’s speculative logic.What results is a significant contribution to the literature, a step-by-step commentary [End Page 536] through one of Hegel’s most underappreciated works. Using diagrams to cut through the often-difficult prose proves to be an excellent strategy. Maybee’s exquisitely detailed and admirably clear exposition makes her a suitable Virgil to guide us through the Inferno of Hegel’s logic.Maybee’s task is to show how Hegel’s logic is, actually, logical, and not, as she puts it, “A jumble of random moves from one step to the next” (xiii). She distinguishes Hegel’s speculative logic from the logic we teach nowadays by emphasizing Hegel’s concern to generate and develop the concepts he employs. That is, he is concerned not merely with the rules connecting the logical terms (i.e. syntax), but also the meanings of the terms themselves (i.e. semantics).As one might expect, these concepts are developed dialectically: two elements that are ordinarily opposed to one another are revealed to be mutually defining and interdependent. Readers already familiar with Hegel’s work will appreciate the way in which Maybee explains complicated ideas like “Actuality” and “spurious infinity.” Maybee has a talent for inventive examples, some of which she carefully carries through the entire work. Also, she has an eye for Hegel’s own examples (see, for instance, the comparison of the Absolute Idea and an old man on 580–82).One of the chief merits of her detailed account is its balanced approach. Instead of perpetuating prevalent but superficial interpretations, she explains the different senses in which something is true. For instance, she distinguishes the different meanings of idealism and shows how Hegel retains some materialist elements in his logic (302). Her knowledge of the history of philosophy helps her to put Hegel’s logic in its proper context. The asides to the Pre-Socratic philosophers and the repeated references to Kant are especially useful.Maybee’s approach to the logic, especially the way in which she frames Hegel’s project, raises interesting philosophical questions. She portrays Hegel as attempting to overcome Kant’s skepticism regarding the unity of thought and being. The question is whether reality is fundamentally accessible to reason, or whether the categories we employ to understand the world are limited to our phenomenal experience.But if Hegel’s logic is supposed to refute the Kantian “thing-in-itself,” we can ask whether this is an intelligible philosophical goal. First, Maybee points out that critics like Nietzsche would ask whether we have to be “committed to logical or conceptual necessity” (130). Perhaps Hegel exhibits a rather typical philosophical bias toward conceptual stability and even necessity. Second, any investigation into logical semantics that is biased in this way inevitably opens Pandora’s Box. Determining the meaning of logical terms is a messy business, and Hegel sometimes seems to stipulate meanings instead of genuinely deriving them. For instance, as Maybee writes, a crucial part of Hegel’s definition of existence is that something is “capable of being experienced” (204). But this simply begs the question against Kant’s “thing-in-itself,” since clearly Kant does not think it exists in this way.Third, given that Maybee points out Hegel’s anthropocentric language, we can ask whether his casual and frequent references to human experience are innocent or self-undermining. For instance, what are we to make of Hegel’s use of ethical examples to explain logical concepts like actuality, necessity, and possibility? A Kantian might... (shrink)

For more than a century, it has been a standard ploy to argue against relativism on the grounds of self‐referential incoherence (e.g., “if the relativists say that beliefs have no objective validity then that belief itself has none,” etc.). This paper determines the particular form this sort of charge takes when applied to a problematic passage in which Kuhn defends his relativistic theory of science by applying that theory to the debate between his critics and himself. If Kuhn were to (...) give up relativism with respect to facts and truth but retain it with respect to the strength of reasons, a pair of dilemmas charging circularity and inconsistency could be circumvented. (shrink)

Hominization theory speculates on the process and chronology of a human embryo’s ensoulment. Aristotle, a key ancient Greek thinker, presented his own hominization theory based on his hylemorphic metaphysics and pioneering researches in embryology. Thomas Aquinas, a medieval philosopher and theologian, built his Christian and Catholic hominization theory on the foundations laid down by Aristotle. The contemporary Roman Catholic Church, with its own prolife, anti-abortion and anticontraception agenda, modified the Aristotelian and Thomistic hominization theories by allegedly benchmarking on recent developments (...) in human embryology. This paper uses the archeological and genealogical methods, as developed by the French poststructuralist and postmodernist philosopher Michel Foucault, in reexamining these three hominization theories as discourses, in comparing and contrasting their epistemic contexts, and in peering into their respective genealogies. Contrary to common assumptions, these three hominization theories have very few elements in common and are actually divergent. The underpinning intention of this paper is to demonstrate the strengths and weaknesses of the contemporary Roman Catholic Church’s hominization theory. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:207 THE CARELESS SKEPTIC THE 'PAMPHILIAN' IRONIES IN HUME'S DIALOGUES In "Hume and the Legacy of the Dialogues" E. C. Mossner sets out a widely accepted interpretation of one of Hume's major intentions in that great work. He argues that Hume's main use of irony therein is to dissimulate with respect to his true religious convictions. The purpose is to provide Hume with a defense against the expected negative (...) reaction to the powerful attack on religion mounted 2 in the Dialogues. The attack, as is well known, is set out in the arguments of Philo against natural and revealed religion as espoused by Cleanthes and Demea, and Philo's views are taken to be those of Hume. It is argued or assumed that since such attacks were in Hume's day imprudent, they must be made by indirection, that is, by a device such as irony. Thus the Dialogues have surface meanings in which the religious views under attack are said (by Pamphilus) to win out; they also have other meanings, underlying or implicit, in which the religious views are conclusively refuted. That they are refuted is a conclusion drawn by the interpreters, in the present case Mossner and those who share his views. These destructive refutations are derived from explication and assessment of the ongoing argument as embodied in the explicit statements of the contestants, and are thus not explicitly linked to Hume. In consequence, quite often from one standpoint (a trivial one of external comment by an immature and prejudiced onlooker) the design argument wins; and from another, more sophisticated one, it loses. The upshot is that "Philo, who as Hume's spokesman for mitigated 208 skepticism will perforce be the victor in the philosophic debate, will nevertheless be 'artfully' depicted as being vanquished by the antagonist." The strategy Mossner finds in the Dialogues thus has the youthful Pamphilus, a ward of Cleanthes, and one who takes no actual part in the adversarial discussions, interposing (in brief asides) comments that superficially but subtly belittle Philo's philosophical position. Philo is characterized, for instance, as having a "careless scepticism," in contrast with Cleanthes, who has an "accurate philosophical turn [of mind]" (D 128). Similarly, at the end of the Dialogues, Pamphilus awards the victory to Cleanthes. In support of his thesis that Philo is a devious Hume's mouthpiece, Mossner brings forth two kinds of evidence, roughly characterizable as external and internal. One kind of external evidence is exemplified in Hume's correspondence with Gilbert 4 5 Elliot of Minto, and Adam Smith; the letters involved are interpreted as showing that Philo represents Hume. Another kind involves comparing the amount of space devoted to the arguments of the three adversaries. The internal evidence is derived from the explication and appraisal of the explicit statements of the contestants; and it is essentially identified with the arguments and conclusions of Philo, except where Cleanthes can be said to make claims which square with those made by Hume in other works such as the Treatise. Thus Hume's views and the related arguments are interpreted as those of Philo, in part because they are considered to be more valid and sound than those of Cleanthes, and in part because they are held to square with the views and arguments affirmed in Hume's other writings. Hume's views, as indicated above, are taken to be those of 209 Philo except where Philo appears to agree with Cleanthes and to accept a form of the design argument. Hume is Cleanthes when Cleanthes sets forth doctrines of the Treatise and the Enquiry that are in accordance with the received (more or less) positivistic interpretation of Hume's skepticism. It is this view that requires that in those places in Parts III, X, and XII, where Philo appears to avow a form of the design argument or to let it stand unrefuted, he be (ironically) dissimulating. Thus the surface victories of Cleanthes and natural religion, which the adversarial flow of the statements of Philo and Cleanthes exhibits, are refuted by the propositions derived from the assessed form and content of the philosophical debate. The basic irony, therefore, lies in aspects of the... (shrink)

Morality is a normative system of guidance that figures into practical reason by telling people what to do in various situations. The problem, however, is that morality has inherent gaps that often render it inefficacious. First, it may be indeterminate due to the high level of generality in which its principles are formulated. Second, moral terms such as ‘good’ and ‘right’ may be so vague that they fail to specify the requisite behavior. And third, its subjective aspect, which is a (...) product of personal experience, generates moral disagreement and thereby creates coordination problems that frustrate society’s collective moral aims. The objective of this article is to advance the thesis that morality must sometimes depend on law as a supplementary source of practical reason, a dependence which can be explained in terms of three essential features of law: its institutional character, its claim to authority, and its status as a second-order exclusionary reason for action. It shall then be explained how these three features enable law to make difficult decisions on behalf of individuals, define objective standards of conduct, and solve coordination problems, respectively, and in doing so, manage to fill in the gaps of morality mentioned above. Hence, it will be argued that law is also a normative system that helps people achieve their moral aims, notwithstanding the fact that it guides human behavior through a different logic and mode of operation from those of morality. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Picturing Hegel: An Illustrated Guide to Hegel’s Encyclopaedia LogicJames A. Dunson IIIJulie E. Maybee. Picturing Hegel: An Illustrated Guide to Hegel’s Encyclopaedia Logic. Lanham, MD: Lexington Books, 2009. Pp. xxvii + 639. Paper, $56.95.If Hegel were alive to read an illustrated guide to his Encyclopaedia Logic, he might not immediately appreciate the project. Not only did he consider “picture-thinking” deficient in comparison to conceptual thinking, but he regarded (...) the Encyclopaedia Logic as a text suitable for German students. In her recent book, Picturing Hegel, Julie Maybee acknowledges these ironies and proceeds to guide those of us who need a little extra help in understanding Hegel’s speculative logic.What results is a significant contribution to the literature, a step-by-step commentary [End Page 536] through one of Hegel’s most underappreciated works. Using diagrams to cut through the often-difficult prose proves to be an excellent strategy. Maybee’s exquisitely detailed and admirably clear exposition makes her a suitable Virgil to guide us through the Inferno of Hegel’s logic.Maybee’s task is to show how Hegel’s logic is, actually, logical, and not, as she puts it, “A jumble of random moves from one step to the next” (xiii). She distinguishes Hegel’s speculative logic from the logic we teach nowadays by emphasizing Hegel’s concern to generate and develop the concepts he employs. That is, he is concerned not merely with the rules connecting the logical terms (i.e. syntax), but also the meanings of the terms themselves (i.e. semantics).As one might expect, these concepts are developed dialectically: two elements that are ordinarily opposed to one another are revealed to be mutually defining and interdependent. Readers already familiar with Hegel’s work will appreciate the way in which Maybee explains complicated ideas like “Actuality” and “spurious infinity.” Maybee has a talent for inventive examples, some of which she carefully carries through the entire work. Also, she has an eye for Hegel’s own examples (see, for instance, the comparison of the Absolute Idea and an old man on 580–82).One of the chief merits of her detailed account is its balanced approach. Instead of perpetuating prevalent but superficial interpretations, she explains the different senses in which something is true. For instance, she distinguishes the different meanings of idealism and shows how Hegel retains some materialist elements in his logic (302). Her knowledge of the history of philosophy helps her to put Hegel’s logic in its proper context. The asides to the Pre-Socratic philosophers and the repeated references to Kant are especially useful.Maybee’s approach to the logic, especially the way in which she frames Hegel’s project, raises interesting philosophical questions. She portrays Hegel as attempting to overcome Kant’s skepticism regarding the unity of thought and being. The question is whether reality is fundamentally accessible to reason, or whether the categories we employ to understand the world are limited to our phenomenal experience.But if Hegel’s logic is supposed to refute the Kantian “thing-in-itself,” we can ask whether this is an intelligible philosophical goal. First, Maybee points out that critics like Nietzsche would ask whether we have to be “committed to logical or conceptual necessity” (130). Perhaps Hegel exhibits a rather typical philosophical bias toward conceptual stability and even necessity. Second, any investigation into logical semantics that is biased in this way inevitably opens Pandora’s Box. Determining the meaning of logical terms is a messy business, and Hegel sometimes seems to stipulate meanings instead of genuinely deriving them. For instance, as Maybee writes, a crucial part of Hegel’s definition of existence is that something is “capable of being experienced” (204). But this simply begs the question against Kant’s “thing-in-itself,” since clearly Kant does not think it exists in this way.Third, given that Maybee points out Hegel’s anthropocentric language, we can ask whether his casual and frequent references to human experience are innocent or self-undermining. For instance, what are we to make of Hegel’s use of ethical examples to explain logical concepts like actuality, necessity, and possibility? A Kantian might... (shrink)

Lists of species underpin many fields of human endeavour, but there are currently no universally accepted principles for deciding which biological species should be accepted when there are alternative taxonomic treatments (and, by extension, which scientific names should be applied to those species). As improvements in information technology make it easier to communicate, access, and aggregate biodiversity information, there is a need for a framework that helps taxonomists and the users of taxonomy decide which taxa and names should be used (...) by society whilst continuing to encourage taxonomic research that leads to new species discoveries, new knowledge of species relationships, and the refinement of existing species concepts. Here, we present 10 principles that can underpin such a governance framework, namely (i) the species list must be based on science and free from nontaxonomic considerations and interference, (ii) governance of the species list must aim for community support and use, (iii) all decisions about list composition must be transparent, (iv) the governance of validated lists of species is separate from the governance of the names of taxa, (v) governance of lists of accepted species must not constrain academic freedom, (vi) the set of criteria considered sufficient to recognise species boundaries may appropriately vary between different taxonomic groups but should be consistent when possible, (vii) a global list must balance conflicting needs for currency and stability by having archived versions, (viii) contributors need appropriate recognition, (ix) list content should be traceable, and (x) a global listing process needs both to encompass global diversity and to accommodate local knowledge of that diversity. We conclude by outlining issues that must be resolved if such a system of taxonomic list governance and a unified list of accepted scientific names generated are to be universally adopted. (shrink)

We present a one per cent measurement of the cosmic distance scale from the detections of the baryon acoustic oscillations in the clustering of galaxies from the Baryon Oscillation Spectroscopic Survey, which is part of the Sloan Digital Sky Survey III. Our results come from the Data Release 11 sample, containing nearly one million galaxies and covering approximately 8500 square degrees and the redshift range 0.2 < z < 0.7. We also compare these results with those from the publicly released (...) DR9 and DR10 samples. Assuming a concordance Λ cold dark matter cosmological model, the DR11 sample covers a volume of 13 Gpc3 and is the largest region of the Universe ever surveyed at this density. We measure the correlation function and power spectrum, including density-field reconstruction of the BAO feature. The acoustic features are detected at a significance of over 7σ in both the correlation function and power spectrum. Fitting for the position of the acoustic features measures the distance relative to the sound horizon at the drag epoch, rd, which has a value of rd,fid = 149.28 Mpc in our fiducial cosmology. We find DV = at z = 0.32 and DV = at z = 0.57. At 1.0 per cent, this latter measure is the most precise distance constraint ever obtained from a galaxy survey. Separating the clustering along and transverse to the line of sight yields measurements at z = 0.57 of DA = and H =. Our measurements of the distance scale are in good agreement with previous BAO measurements and with the predictions from cosmic microwave background data for a spatially flat CDM model with a cosmological constant. © 2014 The Author Published by Oxford University Press on behalf of the Royal Astronomical Society. (shrink)

Aim To explore the views in non-Western cultures about ending the lives of damaged newborns.Method 254 university students from India and 150 from Kuwait rated the acceptability of ending the lives of newborns with genetic defects in 54 vignettes consisting of all combinations of four factors: gestational age ; severity of genetic defect ; the parents’ attitude about prolonging care ; and the procedure used .Results Four clusters were identified by cluster analysis and subjected to analysis of variance. Cluster I, (...) labelled ‘Never Acceptable’, included 4% of the Indians and 59% of the Kuwaitis. Cluster II, ‘No Firm Opinion’, had little variation in rating from one scenario to the next; it included 38% of the Indians and 18% of the Kuwaitis. In Cluster III, ‘Parents’ Attitude+Severity+Procedure’, all three factors affected the ratings; it was composed of 18% of the Indians and 16% of the Kuwaitis. Cluster IV was called ‘Severity+Parents’ Attitude’ because these had the strongest impact; it was composed of 40% of the Indians and 7% of the Kuwaitis.Conclusions In accordance with the teachings of Islam versus Hinduism, Kuwaiti students were more likely to oppose ending a newborn's life under all conditions, Indian students more likely to favour it and to judge its acceptability in light of the different circumstances. (shrink)

Our society has long sanctioned, at least tacitly, a degree of conflict of interest in medical practice and clinical research as an unavoidable consequence of the different interests of the physician or clinical investigator, the patient or clinical research subject, third party payers or research sponsors, the government, and society as a whole, to name a few. In the past, resolution of these conflicts has been left to the conscience of the individual physician or clinical investigator and to professional organizations. (...) The public is no longer willing to allow health care providers to wholly govern their own conflicts of interest for several reasons. These include: new forms of health care financing and delivery that provide innovative and lucrative opportunities for physician or insurer enrichment at patient expense; the increased importance of commercial research support as peer-reviewed governmental research support has decreased; evidence that physicians and clinical investigators too frequently resolve conflicts of interest in their own favor; and a general societal mistrust of authority. This volume represents a multidisciplinary effort, drawing from philosophy, medicine, law, economics and public policy to identify and categorize conflicts of interest in medical practice and clinical research, and, where possible, to offer a mechanism for resolving them. Part I addresses conflicts of interest from a theoretical perspective, offering basic concepts and analytical frameworks. The second part discusses two topics prominent in current health care policy debates--self-referral and financial incentives to limit care. Part III examines conflicts of interest generated by pharmaceutical industry involvement in clinical practice and research. The final section deals with conflicts of interest in clinical research in several contexts, including institutional reviews boards, clinical trials, Cooperative Research and Development Agreements between government and private researchers, brokerage of research subjects by Contract Research Organizations, and cost-effectiveness studies. (shrink)

Locke's main semantic thesis is that words stand for, or signify, ideas. He says this over and over again, though the phraseology he employs varies. In Book III chapter 2 alone we find the following statements of the thesis: ‘ … Words … come to be made use of by Men, as the Signs of their Ideas’ [III.2.1; 405:10-11); The use then of Words, is to be sensible Marks of Ideas; and the Ideas they stand for, are their proper and (...) immediate Signification’ [III.2.1; 405:15-17]; ‘Words in their primary or immediate Signification, stand for nothing, but the Ideas in the Mind of him that uses them’ [III.2.2; 405:21-2]; That then which Words are the Marks of, are the Ideas of the Speaker’ [III.2.2; 405:27-8]; ‘ …. (shrink)

In this paper we raise three questions of clarification about Alfred Mele's fine recent book, Free Will and Luck. Our questions concern the following topics: (i) Mele's combination of 'luck' and 'Frankfurt-style' objections to libertarianism, (ii) Mele's stipulations about 'compatibilism' and the relation between questions about free action and questions about moral responsibility, and (iii) Mele's treatment of the Consequence Argument.

BackgroundConventionally, transcranial direct current stimulation (tDCS) aims to focalize the current reaching the target region-of-interest (ROI). The focality can be quantified by the dose-target-determination-index (DTDI). Despite having a uniform tDCS setup, some individuals receive focal stimulation (high DTDI) while others show reduced focality (“non-focal”). The volume of cerebrospinal fluid (CSF), gray matter (GM), and white matter (WM) underlying each ROI govern the tDCS current distribution inside the brain, thereby regulating focality.AimTo determine the regional volume parameters that differentiate the focal and (...) non-focal groups.MethodsT1-weighted images of the brain from 300 age-sex matched adults were divided into three equal groups- (a) Young (20 ≤ × < 40 years), (b) Middle (40 ≤ × < 60 years), and (c) Older (60 ≤ × < 80 years). For each group, inter and intra-hemispheric montages with electrodes at (1) F3 and right supraorbital region (F3-RSO), and (2) CP5 and Cz (CP5-Cz) were simulated, targeting the left- Dorsolateral Prefrontal Cortex (DLPFC) and -Inferior Parietal Lobule (IPL), respectively. Both montages were simulated for two current doses (1 and 2 mA). For each individual head simulated for a tDCS configuration (montage and dose), the current density at each region-of-interest (ROI) and their DTDI were calculated. The individuals were categorized into two groups- (1) Focal (DTDI ≥ 0.75), and (2) Non-focal (DTDI < 0.75). The regional volume of CSF, GM, and WM of all the ROIs was determined. For each tDCS configuration and ROI, three 3-way analysis of variance was performed considering- (i) GM, (ii) WM, and (iii) CSF as the dependent variable (DV). The age group, sex, and focality group were the between-subject factors. For a given ROI, if any of the 3 DV’s showed a significant main effect or interaction involving the focality group, then that ROI was classified as a “focal ROI.”ResultsRegional CSF was the principal determinant of focality. For interhemispheric F3-RSO montage, interaction effect (p < 0.05) of age and focality was observed at Left Caudate Nucleus, with the focal group exhibiting higher CSF volume. The CSF volume of focal ROI correlated positively (r ∼ 0.16, p < 0.05) with the current density at the target ROI (DLPFC). For intrahemispheric CP5-Cz montage, a significant (p < 0.05) main effect was observed at the left pre- and post-central gyrus, with the focal group showing lower CSF volume. The CSF volume correlated negatively (r ∼ –0.16, p < 0.05) with current density at left IPL. The results were consistent for both current doses.ConclusionThe CSF channels the flow of tDCS current between electrodes with focal ROIs acting like reservoirs of current. The position of focal ROI in the channel determines the stimulation intensity at the target ROI. For focal stimulation in interhemispheric F3-RSO, the proximity of focal ROI reserves the current density at the target ROI (DLPFC). In contrast, for intrahemispheric montage (CP5-Cz), the far-end location of focal ROI reduces the current density at the target (IPL). (shrink)

A considerable literature exists regarding the moral obligation to keep one's promises. Several authors have focused on the exceptional circumstances which may or should excuse this moral duty. Less frequently discussed is the question of how this general moral obligation and its possible exceptions play out in the context of negotiable written promises to pay money, i.e., so-called "commercial paper." This paper focuses on the application of the legal rules governing commercial paper, and on the ethical implications involved in the (...) application of those rules. More specifically, it asks whether the assertion of the technical doctrine known as "holder in due course," and the denial of that status in some cases, promotes ethical behavior in the marketplace. By examining the circumstances of one case, involving a substantial investment and a large bank, I hope to shed some light on how the legal and ethical rules do in fact "intersect.". (shrink)

In remote regions of the eastern Andaman, into the 1990s, a remarkable rapport with nature's forces was occurring.1 Most strikingly expressed during adolescence, it emerged spontaneously from a local type of consciousness. Both the capability and the underlying consciousness were conceived within a pervasive milieu of lushly sensual infant nurture.2 So dependable was the pattern of affection, it spawned a tactile language long before onset of speech. Speech, learning and sociality then followed in the eros‐driven paradigm already set. So did (...) a rare rapport with nature's forces.With nothing in the culture to discourage it, eros was not walled‐off as children grew. It remained firmly at the root of consciousness on through teens. To be a child out in those seas was to move spontaneously and digressively out into life pursuing sundry passion pulses. When erotic power escalated during adolescence, rapport with natural forces dramatically increased. Spectacular gambolings with nature began bursting forth—sometimes astonishingly complex rhythmic ones. No clouds of moody adolescent angst discouraged spontaneity; no flattening of affect suppressed adolescent verve; no emotional dissimulation confounded purpose. Adolescence was a time for a blossoming of affect, for melding deeply and dynamically with habitat. It was a time to profoundly dance with nature's forces.Possessing a protean character, love lies more fluidly within the human frame than language. Following its own inner protocols, love seems able to evade the stable kinds of labeling required for logical inquiry. In exotic cultures it is hard to see at all. In the eastern Andaman, its workings were initially invisible to Western eyes. It was necessary to firm up subliminal awarenesses before the workings out of eros could even be detected there. Though difficult to deal with scientifically, love plays such a profound role in the affairs of humankind that it begs experimental types of scrutiny.A fracturing of love into Bacchanalian and Sublime occurred during the early Greek foundations of Western culture. Out of that schism Western ethos grew. The ethos molded the Western type of consciousness. In the eastern Andaman, eros was not cleaved at all. It shaped a type of psyche not countenanced by the West since its prehistory. (shrink)